ZIA CP010144 - 07160 (ZIA) | |||
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Title | ITCLC Familial Testicular Cancer Projects | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Greene, Mark | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $166,543 | Project Dates | 07/01/2002 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Testes (100.0%) | ||
Research Type | |||
Cancer-Related Biology Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The Clinical Genetics Branch was a member of the International Testicular Cancer Linkage Consortium (""ITCLC""), a scientific collaboration dedicated to mapping and cloning the genes related to testicular cancer susceptibility in humans. This organization has ceased to function, and has been supplanted by the Testicular Cancer Association Consortium (""TECAC""). There were three components to our collaboration with the ITCLC: 1. We contributed DNA from newly-ascertained US testicular cancer families to ITCLC effort, and have continued to do so with TECAC, which is focusing on GWAS analysis of TGCT susceptibility genes. 2. We capitalized on the large set of European families which has already been assembled by the ITCLC by taking the scientific lead in designing and conducting two additional studies: (a) a centralized review of the pathology of a large series of familial testicular cancers and a comparison group of non-familial testicular cancers. This analysis is ongoing. (b) a formal, quantitative analysis of the occurrence of cancers other than testicular cancer in these families. Our data suggest that FTGCT is a site-specific syndrome: we found no excess risk of other cancers. 3. We have published a descriptive analysis of the ITCLC testicular cancer family set (n=350), the largest collection of multiple-case families extant. The goal of this project was to identify etiologically homogenous subsets of families which might be more amenable to linkage-based gene discovery. In general, the risk factor profile of familial TGCT cases was surprisingly similar to that of sporadic TGCT. 4. Data from the 5 major ITCLC contributors demonstrated convincingly, for the first time, that age-at-diagnosis of familial TGCT is significantly younger than its sporadic counterpart. " |