ZIA CP010176-10082 (ZIA) | |||
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Title | KS gene expression & clonality | ||
Institution | NCI, Bethesda, Ma | ||
Principal Investigator | Mbulaiteye, Sam | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $70,868 | Project Dates | 01/24/2004 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Kaposi Sarcoma (100.0%) | ||
Research Type | |||
Cancer Related Biology Exogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Uganda Gene Expression Study. This study addresses two key components of KS pathogenesis. First, the study will examine whether multiple KS lesions in a single individual represent separately arising tumors or all represent a single clone. Second, the study will characterize the patterns of viral and human gene expression in the KS lesions. The study is accrued fresh frozen pathologic KS and normal skin tissues, plasma and buffy coat from adults with KS in Uganda. Tissues from recently deceased subjects with KS were also being obtained. A hypothesis that whole KS cells can be transmitted sexually was examined in 25 women by looking for presence of Y-chromosome in KS tumor cells as compared to normal cells. None were positive. Data on human herpesvirus 8 load in peripheral blood has been analyzed and shown to be associated with KS progression and, to a lesser extent, with KS burden. Other correlates include low hemoglobin and low platelets. Future studies are planned to examine cytogenetic abberations using high-density genetic polymorphic markers and to examine the role of gene-methylation in KS pathogenesis. |