ZIA CP010131-04140 (ZIA) | |||
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Title | Second cancers following retinoblastoma | ||
Institution | NCI, Bethesda, Ma | ||
Principal Investigator | Kleinerman, Ruth | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $212,901 | Project Dates | 01/01/1987 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (100.0%) Childhood Cancers (100.0%) Smoking Behavior (10.0%) |
Breast (2.0%) Lung (3.0%) Melanoma (30.0%) Sarcoma (60.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
The NCI has been studying a series of 2,000 - one year survivors of retinoblastoma (RB) diagnosed 1914-2006. Patients with hereditary RB had a 36% chance of developing specific cancer if they survived to age 50, whereas patients with non-hereditary RB had only a 5% chance of developing another cancer if they survived to age 50. The purpose of this Retinoblastoma Study is to determine if specific mutations in the RB1 gene may be associated with increased risk for development of a second cancer, and to continue to determine second cancer risk. Annual searches of the National Death Index are performed periodically to determine mortality in the cohort for the purpose of updating vital status and obtaining cause of death in the cohort. S-5297-45 (old protocol number) |