ZIA CP010212-10092 (ZIA) | |||
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Title | Clonal expansion of lymphocytes in multiple cohorts | ||
Institution | NCI, Bethesda, Ma | ||
Principal Investigator | Rabkin, Charles | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $56,608 | Project Dates | 01/24/2004 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Hodgkins disease (5.0%) Leukemia (5.0%) Multiple Myeloma (5.0%) Non Hodgkins Lymphoma (85.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
We are examining the role of genomic instability in the etiology of NHL with HIV-infection as well as in the general population, using materials from cohort and case-control studies conducted by the Branch and others in the Division of Cancer Epidemiology and Genetics. This project builds upon the Branch's previous observation of the t(8;14) translocation in circulating lymphocytes from HIV-infected patients without NHL. Lymphoma specimens from the Prostate Lung Colorectal and Ovarian (PLCO) cancer screening trial have been tested for consenses translocation sequences of t(14;18) and t(11;14). Prediagnostic peripheral blood lymphocytes will be examined for oncogenic chromosomal translocations associated with risk of subsequent NHL and/or clonally related to these tumors. Lymphoma specimens will be examined for tumor suppressor gene and oncogene alterations, and viral DNA sequences. Nested case-control and cohort analyses will be used to determine risk factors for these abnormalities, and their association with risk of subsequent NHL. |