ZIA CP010214-10419 (ZIA) | |||
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Title | Microbial diversity and human malignancy | ||
Institution | NCI, Bethesda, Ma | ||
Principal Investigator | Goedert, Jim | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $180,616 | Project Dates | 01/01/2008 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (40.0%) Hodgkins disease (20.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Technology Development and/or Marker Discovery |
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Abstract | |||
Increasingly, it is recognized that commensal microbes substantial affect human health and disease through various mechanisms. The studies human population studies are focused on two primary areas. The first is that less intestinal (fecal) microbial diversity is associated with a higher risk of Hodgkin lymphoma. Specifically, fecal microbial diversity is compared in survivors of adult HL and co-twin controls who have not developed HL. The second is examining whether differences in fecal microbes, and specifically in their beta-glucuronidase activity that deconjugates estrogens allowing them to be reabsorbed from the gut into the circulation, are associated with differences in systemic estrogens. The latter are strong predictors of subsequent risk for breast cancer. -based. Some studies use molecular markers, such as gene markers, serum or tissue markers of infection, and cytokine levels indicating inflammation. Other studies evaluate human genetic polymorphisms that may affect inflammation and immunity and thereby modulate cancer risk.. |