ZIA CP010150 - 10098 (ZIA) | |||
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Title | Lung cancer, infections & immunity | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Engels, Eric | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $38,291 | Project Dates | 03/29/2004 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Lung (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The lung is a site for repeated or chronic inflammatory insults. Epidemiologic research has provided evidence in support of the hypothesis that tissue damage caused by inflammation can initiate or promote development of lung cancer, possibly in conjunction with tobacco use. For example, some studies suggest an increased risk of lung cancer among persons with lung infections, such as tuberculosis or bacterial pneumonia, or inflammatory lung diseases. Elevated serum levels of C-reactive protein, an inflammation marker, are associated with heightened lung cancer risk. Recent studies also demonstrate increased lung cancer risk among immunosuppressed individuals infected with human immunodeficiency virus. Other research indicates an association between genetic polymorphisms in the inflammation pathway, which might modulate the inflammatory response, and lung cancer risk. |