ZIA CP010126 - 10598 (ZIA) | |||
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Title | Ghana Breast Cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Brinton, Louise | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $1,702,947 | Project Dates | 04/05/2011 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (50.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Background: There currently exists scant information on breast cancer that occurs among African women, although data suggest that, like African-American women, the cancers that develop among African women tend to occur at younger ages and have worse prognostic features than those occurring among American Caucasians. Given that breast cancer incidence rates are increasing in many African nations and that treatment options are limited, there is a critical need for better understanding the pathogenesis and identifying risk factors that might be used in primary prevention. Following a successful one year pilot, we initiated a 2-year case-control study at three hospitals in Ghana, Korle Bu Teaching Hospital in Accra and Komfo Anoyke Teaching Hospital and Peace and Love Hospital in Kumasi. The main aims of this study are to perform careful pathologic classification of breast tumors in order to relate a variety of risk factors to distinctive tumor subtypes. As eligible cases, we are including women 18-74 years of age who are diagnosed and/or treated for incident breast cancer at our study hospitals. Population controls were identified through household sampling, based on data provided by the 2010 Ghanaian census. Both case and control subjects are being interviewed, anthropometric measurements taken, and requests made for blood, saliva and fecal specimens. Breast tissue samples are being acquired from the breast cancer cases. It is anticipated that approximately 2000 cases and 2000 controls will be included in this investigation, which is anticipated to be completed late in 2015. |