ZIA CP010215 - 10521 (ZIA) | |||
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Title | Evaluation of Skin, Colonic Vaginal, Penile and Oral Microbiome and Effect of Ti | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Safaeian, Mahboobeh | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $198,533 | Project Dates | 01/01/2009 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Cervical Cancer (50.0%) | ||
Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Resources and Infrastructure Related to Detection, Diagnosis, or Prognosi |
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Abstract | |||
The study of infectious agents and their role is disease is not new with most efforts focusing on specific agents, such as HPV and cervical cancer, Helicobacter pylori (HP) and gastric diseases and carcinoma, hepatitis B and C virus and liver cancer, to name a few. The body?s skin and mucosal surface?s play host to microbial communities whose membership outnumbers our own somatic and germ cells by an order of magnitude or more. The skin, oral, and gastrointestinal tract are all densely colonized surfaces. Recent technological advances have made exploration of the microbiome, an understudied area, feasible. It is reasonable to hypothesize that some of the infectious agents that naturally reside in the body may impact health, or that perhaps the balance between the various micro-organisms has an effect on health. This new field of study has much promise that could lead to important discoveries of how infectious agents are associated with disease and how environmental and host responses to these agents determine patterns of colonization and subsequent disease risk. However, because the study of the human microbiome is a new research area, much remains to be learned regarding such as the extent and pattern of the microbiome at various site and determinants of these patterns. Prior to launching large-scale epidemiological studies to evaluate the association between microbiome and disease, it is crucial to conduct well-designed, systematic, methodological studies to address some of the issues listed above. These methodological studies will begin to provide the baseline information that could be used to plan for, and conduct disease association studies. We propose to add to an existing randomized clinical trial protocol to eradicate HP to include collection of oral, skin, and colonic samples at randomization, immediately following therapy (at 6 weeks) and one year after therapy on up to 200 (150 expected) HP-positive and 50 HP-negative individuals. |