ZIA CP010180 - 01072 (ZIA) | |||
---|---|---|---|
Title | Prostate tissue study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Cook, Michael | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $25,319 | Project Dates | 01/01/1999 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Prostate (100.0%) | ||
Research Type | |||
Cancer-Related Biology
Endogenous Factors in the Origin and Cause of Cancer |
|||
Abstract | |||
Although androgens have been the central hypothesis in prostate cancer etiology for decades, epidemiologic studies in humans have not been able to confirm this hormonal hypothesis. Most of the studies use sera to examine the relationships of circulating hormones with subsequent prostate cancer risk. However, it is possible that circulating levels of hormones may not reflect intraprostatic androgenic activity accurately. To gain further insights and to provide directions for future epidemiologic studies, this comprehensive methodogical study. The specific aims of this study are: - to correlate circulating levels of androgens and estrogens with tissue levels (including testosterone, DHT, DHT sulfate, androstenedione, androstanediol glucuronide, estradiol, estrone, and estrone sulfate); - to determine whether the serum-tissue correlation is mediated by age, race, and selected epidemiologic factors, such as smoking and body size; - to determine whether tissue hormone levels correlate with polymorphisms of certain hormone-related genes, including androgen receptor and SRD5A2; and - to correlate circulating levels of hormones with intraprostatic androgenicity, as defined by the combined levels of tissue hormones, androgen receptor, and its associated protein (ARA70). |