ZIA CP010120 - 02060 (ZIA) | |||
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Title | A cohort study among workers exposed to benzene in China | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Rothman, Nathaniel | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $164,963 | Project Dates | 01/01/1987 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Leukemia (40.0%) Lung (20.0%) Multiple Myeloma (20.0%) Non Hodgkins Lymphoma (20.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
Although benzene is an important environmental and occupational exposure, the spectrum of disease and level of risk associated with exposure are not well understood. Our epidemiologic investigations conducted in China on the largest benzene-exposed cohort ever assembled (75,000 benzene-exposed versus 35,000 unexposed workers in China employed during 1949-87) suggest that benzene is associated with a variety of hematologic neoplasms in humans. Furthermore, biochemical studies in this population identified benzene-related cytogenetic effects and genetic susceptibility factors. Investigations continue to specify dose-response and biologic mechanisms of disease in benzene-exposed workers, including a GWAS of benzene hematotoxicity. |