ZIA CP010200 - 10470 (ZIA) | |||
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Title | GEI - Lung | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Caporaso, Neil | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $125,496 | Project Dates | 01/12/2009 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Lung (100.0%) | ||
Research Type | |||
Cancer Progression & Metastasis Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This project covers DCEG whole genome scan research and other activities that were originally part of the Genes, Environment and Health Initiative (GEI) but now extend more broadly to GWAS studies conducted elsewhere in DCEG and also consortial work (i.e., with TRICL and GAME-ON). Research activities currently underway include studies of lung cancer and smoking based on GWAS data originating from the EAGLE study and the lung cancer etiology arm of the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial. We continue to actively mine this rich data to test candidate genes hypotheses, participate in consortia, investigate interesting disease subsets (i.e., by histology), investigate outcome (survival in early stage), explore behaviors related t ocancer (i.e., the Fagerstrom Index, depression, etc.) and key exposures related to cancer (smoking, alcohol, and caffeine). We are planning to also investigate our GWAS data in relation to diverse genomic and molecular studies being conducted such as sequencing (paired tumor and nontumor on special subsets), methylation studies, expression studies (conducted on tissue and blood on a subset), cytokine assays, DNA repair studies, and chromosome abnormalities. |