Title |
Targeting Multiple Diseases Through Gamma Secretase
|
Institution |
UNIVERSITY OF MASSACHUSETTS AMHERST, HADLEY, MA
|
Principal Investigator |
OSBORNE, BARBARA
|
NCI Program Director |
Spalholz
|
Cancer Activity |
Cancer Cell Biology
|
Division |
DCB
|
Funded Amount |
$951,325
|
Project Dates |
09/20/2013 - 08/31/2018
|
Fiscal Year |
2017
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Aging (19.0%)
Cancer (100.0%)
Metastasis (18.0%)
Organ Transplantation Research (24.0%)
|
Brain (19.0%)
Breast (56.0%)
Leukemia (26.0%)
|
Research Type |
Systemic Therapies - Discovery and Development
Education and Communication Research
|
Abstract |
"DESCRIPTION (provided by applicant): This Program proposes an overarching hypothesis that rational targeting of ?-secretase, a multi-subunit intramembrane cleaving protease that has several biologically important substrates, may be considered as a therapeutic target for a number of diseases. The three projects in this Program address the use of ?-secretase inhibitors in breast cancer (Project 1), and graft-versus-host disease (Project 2), and propose biochemical strategies to enable us to better understand the mechanism of action of ?-secretase (Project 3). These projects are integrated with a goal of better understanding the mechanism of action of ?-secretase inhibition in normal, as well as, disease settings. The Principal Investigators of this Program have worked together, shared data and published as a group for the past six years. The Program is significantly enhanced by a Chemistry Core that has the proven ability to synthesize a wide variety of ?-secretase inhibitors that allow members of the Program to explore the biological properties of these inhibitors in an environment free from commercial restriction. Such an approach will provide a scientific basis for optimal GSI selection matched to a particular disease." |