Title |
The Tisch Cancer Institute - Cancer Center Support Grant
|
Institution |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY
|
Principal Investigator |
PARSONS, RAMON
|
NCI Program Director |
Shafik
|
Cancer Activity |
Multidisciplinary
|
Division |
OCC
|
Funded Amount |
$2,373,000
|
Project Dates |
08/01/2015 - 07/31/2020
|
Fiscal Year |
2018
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Cancer (100.0%)
Aging (3.0%)
Basic Behavioral and Social Science (2.0%)
Behavioral and Social Science (6.0%)
Biochemical Epidemiology (2.0%)
Bioengineering (1.0%)
Bone Marrow Transplantation (3.0%)
Cancer Survivorship (12.0%)
Chemotherapy (5.0%)
Chronic Myeloproliferative Disorders (14.0%)
Depression Research (5.0%)
Diabetes (6.0%)
Digestive Diseases (4.0%)
Metastasis (11.0%)
Nuclear Magnetic Resonance Imaging (NMR) (1.0%)
Organ Transplantation Research (8.0%)
Sleep Disorders (6.0%)
Surgery (5.0%)
|
Brain (1.0%)
Breast (18.0%)
Colon/Rectum (2.0%)
Head and Neck (3.0%)
Leukemia (22.0%)
Liver Cancer (2.0%)
Lung (7.0%)
Melanoma (6.0%)
Multiple Myeloma (3.0%)
Non Hodgkins Lymphoma (3.0%)
Prostate (5.0%)
Sarcoma (1.0%)
|
Research Type |
Resources & Infrastructure Related to Biology
Resources and Infrastructure Related to Etiology
Resources and Infrastructure Related to Prevention
Resources and Infrastructure Related to Detection, Diagnosis, or Prognosis
Resources and Infrastructure Related to Treatment and the Prevention of Recurrence
Resources and Infrastructure Related to Cancer Control, Survivorship, and Outcomes Research
|
Abstract |
? DESCRIPTION (provided by applicant): Cancer progression is characterized by gradual dysregulation of the immune system at multiple levels that is considered to directly contribute to unchecked tumor growth. The central theme of the Cancer Immunology (CI) Research Program is to identify mechanisms underlying the suppression of effective anti-tumor immunity that could instruct the development of novel and impactful immunotherapies. Dendritic cells (DCs), potent antigen presenting cells, initiate anti-tumor immune responses, which are subsequently mediated by CD4+ helper cells and cytotoxic T cells. Immunologists have historically focused on characterizing the role of tumor infiltrating T cells (TILs) in restraining tumor growth, but thereis emerging evidence that innate immune cells, such as DC and macrophages, are strongly affected by the tumor micro-environment (TME) and major contributors to tumor progression. The CI Research Program has three main scientific objectives. They are to: 1) Characterize mechanisms underlying DC and macrophage immune dysregulation in the tumor micro-environment; 2) Develop preclinical models to reverse innate immune dysfunction and restore immunogenicity to tumor associated antigens, and 3) Translate preclinical discoveries into cancer immunotherapy trials. The CI program has 21 members, and they represent 10 departments and 3 institutes (The Tisch Cancer Institute, Immunology Institute, Icahn Institute for Genomics and Multiscale Biology). As of July 1, 2014, program members were awarded $4,016,010 in NCI and other peer reviewed cancer-related direct support. Members of the CI Program have been increasingly successful in publishing their research in high impact journals. Since 2011, CI program members published 163 reports, of which 14.7% were intra-programmatic and 23.9% inter-programmatic. " |