Title |
The Pacific Northwest Prostate Cancer SPORE
|
Institution |
FRED HUTCHINSON CANCER RESEARCH CENTER, SEATTLE, WA
|
Principal Investigator |
NELSON, PETER
|
NCI Program Director |
Hruszkewycz
|
Cancer Activity |
Translation Research (formerly Organ Systems)
|
Division |
DCTD
|
Funded Amount |
$2,155,387
|
Project Dates |
09/19/2002 - 08/31/2023
|
Fiscal Year |
2018
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Cancer (100.0%)
Biochemical Epidemiology (20.0%)
Genetic Testing (20.0%)
Metastasis (56.0%)
|
Prostate (100.0%)
|
Research Type |
Cancer Progression & Metastasis
Resources & Infrastructure Related to Biology
Technology Development and/or Marker Discovery
Technology and/or Marker Testing in a Clinical Setting
Systemic Therapies - Discovery and Development
Systemic Therapies - Clinical Applications
|
Abstract |
PROJECT SUMMARY/ABSTRACT The Pacific Northwest (PNW) Prostate Cancer SPORE continuation grant represents a coordinated effort of four institutions with established programs and strengths in translational prostate cancer research including basic, clinical, and population sciences as well as career development: 1) the Fred Hutchinson Cancer Research Center (FHCRC); 2) the University of Washington (UW) and its affiliated institutions; 3) the University of British Columbia and the Prostate Centre of Vancouver General Hospital (UBC); and 4) Oregon Health and Science University (OHSU). These Seattle-, British Columbia- and Portland-based institutions have large multidisciplinary teams of investigators and laboratories dedicated to prostate cancer research and a history of working closely together within this larger milieu. The respective teams of clinicians and researchers at these institutions bring considerable scientific depth, breadth, creativity, and vision required for confronting the most challenging problems blocking progress in our ultimate goal of reducing the morbidity and mortality associated with prostate cancer. This SPORE proposal enlarges the blueprint for a well-built, distinctive and coordinated translational prostate cancer research effort spanning the entire PNW. All participating institutions have made substantial commitments toward supporting the SPORE and its innovative, translational projects: 1) Molecular predictors of prostate cancer progression and mortality; 2) Targeting Emergent Vulnerabilities in AR-Inactive Prostate Cancer; 3) Oncofetal Glycosaminoglycans as Molecular Targets in Prostate Cancer; 4) Clinical Development of Therapeutic Strategies Targeting Damage Repair; and 5) Exploiting mechanisms of response and resistance to next generation androgen pathway antagonists. We also propose four Cores to support these projects: 1) Leadership and administration; 2) Biospecimens; 3) Biostatistics and Data Analytics; and 4) Clinical research. In addition, we propose a Developmental Research Program and a Career Enhancement Program that will significantly embellish and strengthen the translational goals of our prostate cancer research program and expand opportunities for engaging young as well as established investigators in our multidisciplinary environment." |