Z01 BC 010541 (Z01) | |||
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Title | Development of Mouse Astrocytoma Model for Preclinical Testing of Experimental Th | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Reilly, Karlyne | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $76,229 | Project Dates | 10/01/2003 - N/A |
Fiscal Year | 2007 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Chemoprevention (50.0%) Chemotherapy (50.0%) Childhood Cancers (70.0%) Neurofibromatosis (70.0%) Neurosciences Research (100.0%) Nuclear Magnetic Resonance Imaging (NMR) (50.0%) |
Brain (100.0%) Nervous System (100.0%) |
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Research Type | |||
Combinations of Localized and Systemic Therapies Application of Model Systems |
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Abstract | |||
Astrocytoma is currently incurable due to its diffuse infiltration and the lack of effective therapies. We are developing a mouse model of spontaneous astrocytoma through mutation of Nf1 and p53. The astrocytomas in these mutant mice show diffuse infiltration throughout the central nervous system and form secondary structures around neurons and blood vessels recapitulating the pathology seen in human astrocytomas. We are developing methods for imaging astrocytomas in live animals and quantitating tumor burden in order to use this model for testing experimental therapeutics. |