ZIA CP010119 02020 (ZIA) | |||
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Title | Prospective study of farmers and their families (Agricultural health study) | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Beane Freeman, Laura | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $592,688 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Depression Research (5.0%) Diabetes (10.0%) Pesticides (100.0%) Childhood Cancers (10.0%) |
Bladder (5.0%) Breast (5.0%) Colon/Rectum (5.0%) Leukemia (10.0%) Lung (10.0%) Melanoma (5.0%) Multiple Myeloma (10.0%) Non Hodgkins Lymphoma (15.0%) Pancreas (5.0%) Prostate (10.0%) Thyroid (5.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The stimulus for this prospective investigation comes from the growing evidence that, despite a low mortality overall, farmers experience an excess of several cancers. Excess cancers are observed for the lymphatic and hematopoietic system, connective tissue, skin, brain, prostate, stomach and lips. Several of these tumors (brain, NHL, multiple myeloma, and prostate) are also increasing in the general population in many of these countries. Cancer studies within the Agricultural Health Study now confirm that pesticides and other occupational exposures in the agricultural environment can also lead to excess disease risk including cancers of the prostate, lung, pancreas, colon, rectum, bladder and malignant melanoma. Non-cancer studies confirm that nonmalignant respiratory disease and neurological symptoms are elevated among those with certain pesticide exposures and other occupational exposures. Farmers, their families, and other pest control workers may have contact with a variety of potentially hazardous substances including pesticides, solvents, fuels and oils, engine exhaust, dust and zoonotic viruses and other microbes. This cohort includes registered pesticide applicators in IA and NC and the spouses of the applicators who are farmers. The health effects of pesticide use are the primary focus of the study including both cancer and other chronic diseases. The influence of other farm exposures is also being evaluated. The focus of the phase 3rd follow-up period has been assessing etiology of cancer and non-cancer diseases and beginning mode-of-action studies. The 4th phase of the study started on September 23, 2011 will continue disease etiology studies and mechanistic studies of cancer. We have begun administering a cohort-wide questionnaire in June 2013, along with continued work on substudies including BEEA, lung health, MRSA and parkinson disease. Other protocols: 09-C-N143; 08-C-N073 |