ZIA CP010126 01103 (ZIA) | |||
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Title | Columbia, Missouri serum bank participant extended follow-up | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Benson, Gretchen | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $22,524 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (80.0%) Ovarian Cancer (10.0%) Uterine (10.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This investigation has followed women who donated serum to the Columbia, MO serum bank beginning in the mid 1970s to ascertain the development of subsequent cancer and deaths. The Columbia, MO serum bank was established as part of the National Cancer Institute's Biological Markers Project to identify serum markers for breast cancer. Patients have been traced and asked to complete a short questionnaire regarding subsequent development of cancers. A linkage of cohort members with the National Death Index has also been completed. Self-reports of breast cancers have been validated through retrieval of medical records, and attempts are underway to retrieve similar information for self reports of other cancers. Data relevant to the ovarian and endometrial cancers that have developed among cohort members have used as part of a collaborative analysis of hormonal predictors of risk and several manuscripts have been published. We have assessed relationships of adipocytokines to endometrial cancer risk using samples from this study. More recently, we have measured estrogen metabolites via an LC-MS assay and related these measurements to breast cancer risk. This showed significant relationships with parent estrogens and some evidence that those with more extensive hydroxylation along the 2-pathway might be at reduced risk. A new pooling project has begun in which samples from this study are being assayed for anti-Mullerian substance. |