ZIA CP005803 10804 (ZIA) | |||
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Title | Genomic Characterization of Normal Breast Tissue | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Machiela, Mitchell | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $13,239 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Cancer Initiation: Alterations in Chromosomes Resources and Infrastructure Related to Etiology |
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Abstract | |||
Genomic characterization of breast cancer typically involves the study of tumor specimens or adjacent margin tissue. Such studies provide an etiologic window into the final set of acquired mutations in a tumor, but seldom provide insight into the temporal process and ordering of acquired mutations responsible for transforming normal breast tissue into premalignant lesions and breast carcinoma. To date, relatively little is known regarding early genomic mutations that drive breast cancer risk. Herein, we propose to characterize the frequency and distribution of early DNA copy number changes in healthy breast tissue that may influence histologic and transcriptomic changes in cellular subpopulations. We will investigate whether breast cancer risk factors (genetic and non-genetic) are associated with somatic copy number changes in normal breast tissue, and whether such somatic changes are related to intermediate markers of breast cancer risk, namely terminal duct lobular unit (TDLU) involution and mammographic breast density. We hypothesize that extensive characterization of somatic copy number changes in normal breast tissue could identify early genetic alterations that inform our understanding of breast cancer etiology as well as identify novel biomarkers useful in personalized prevention. |