Z01 CP005803-08050 (Z01) | |||
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Title | Brain tumor family study of genetic susceptibility and environmental factors | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Goldstein, Alisa | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $5,408 | Project Dates | 09/01/1998 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (5.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Brain (45.0%) Central Nervous System - Not Including Brain (10.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
Few risk factors are known with certainty for brain tumors in adults and only a few have been implicated in its pathogenesis. To advance understanding of environmental, behavioral and genetic causes of brain tumor in adults, a multicenter case-control study of malignant and benign brain tumors in adults was initiated in 1994. Information about a broad range of possible environmental, lifestyle, and genetic risk factors was obtained from both cases and controls through a computer-assisted personal interview. The family history component obtained history and age at diagnosis of cancer or benign brain tumors and selected other diseases, for all living and deceased first degree relatives. A supplemental self-administered questionnaire covered diet, vitamin supplements, alcohol consumption, and household use of electrical appliances. Blood samples were obtained as a source of DNA. Currently, data analysis is in the early stages. A family studies component to the case-control study focus |