ZIA CP010219-10682 (ZIA) | |||
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Title | Cancer registry-linkage studies of thyroid cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Kitahara, Cari | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $17,333 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Contraception and Reproduction Research (25.0%) |
Thyroid (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
"""The purpose of this project is to test novel hypotheses regarding the higher incidence of thyroid cancer in women compared with men, especially during the reproductive period. Pregnant women are at increased risk of hypothyroidism, characterized by elevated levels of thyroid stimulating hormone, thyroid autoimmunity, and goiter, an established risk factor for thyroid cancer, due to an increase in thyroid hormone requirements, increased renal iodine loss, and increased fetal iodine requirements. Inadequate control for thyroid function has been associated with numerous pregnancy-related complications. Individuals whose mothers experienced pregnancy complications may also be at increased risk of thyroid cancer due to imbalances in pregnancy-related hormones or iodine deficiency in utero which could potentially initiate thyroid cancer development in very early life. This project involves linking data on pregnancy complications and birth characteristics from Danish, Swedish, Norwegian, and Finnish Medical Birth Registers with nationwide Cancer Registry data for these four countries and examining the associations between these factors and risk of thyroid cancer in the mothers and their offspring.""" |