ZIA CP010124 01015 (ZIA) | |||
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Title | ALTS | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Castle, Philip | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $35,234 | Project Dates | 09/18/2002 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Cervical Cancer Education (70.0%) |
Cervical Cancer (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Resources and Infrastructure Related to Detection, Diagnosis, or Prognosis |
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Abstract | |||
DCEG funds specific aspects of testing and analysis of specimens from the DCP-funded ALTS project. The final analyses are still underway for the ALTS trial of 5,000 women with abnormal cytology followed for 2 years. Based on HPV typing of all 20,000 specimens from these participants, we are examining the diverse natural histories of the carcinogenic and non-carcinogenic HPV types, and the influences of co-factors. We are interested in all projects in determining the strength of the relationship between viral persistence and precancer diagnosis. Many data analyses are underway for the Guanacaste Project, for example: 1) All aspects of HPV DNA, cytology, and visual appearance of the cervix among the 10,000 women during the 7 years of follow-up, 2) Examining the relationship of cervical immune profiles and the development of high-grade cervical neoplasia, 4) HPV type variants and risk of viral persistence and progression, and 5) The acquisition of sexually transmitted infections and the onset of cervicitis after sexual debut. We are finding that multiple infections, though very common, show little evidence of synergy or antagonism with regard to either persistence or neoplastic progression. |