ZIA CP010144 08040 (ZIA) | |||
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Title | Hereditary Breast/Ovarian Cancer Families - Master Protocol | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Greene, Mark | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $41,069 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Chemoprevention (20.0%) |
Breast (40.0%) Ovarian Cancer (35.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interventions to Prevent Cancer: Personal Behaviors (Non-Dietary) that Affect Cancer Risk |
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Abstract | |||
This study encompasses the legacy collection of hereditary breast/ovarian cancer kindred that have been under evaluation since the late 1970's. It consisted of 70 heavily-loaded HBOC families, 33 with known <i>BRCA1/2</i> mutations that which contributed to the mapping of <i>BRCA1</i> and <i>BRCA2</i> and development of evidence-based approaches to clinical management. Since the founding of the Clinical Genetics Branch, additional analyses of these families have: (1) documented a two-fold increase risk of prostate cancer among carriers of Ashkenazi Jewish founder mutations; (2) suggested that breast cancer risk among mutation-negative women from <i>BRCA1/2</i> mutation-positive families was similar to that observed in the general population; (3) documented that risk-reducing salpingo-oophorectomy prospectively and significantly reduced the risk of breast cancer among <i>BRCA1</i> mutation carriers; (4) supported a total of 39 CIMBA-related publications, of which 25 are new publications (plus 8 more currently under review) since the last Site Visit; and (5) provided annotated biospecimens for multiple translational research projects. This protocol is now inactive clinically, but we continue to seek new opportunities to leverage our biospecimen collection for additional etiologic research. |