ZIA CP010195-03031 (ZIA) | |||
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Title | ATBC Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | N/A | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $1,161,432 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (5.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (5.0%) Chemoprevention (20.0%) Digestive Diseases (15.0%) |
Bladder (4.0%) Brain Colon/Rectum (10.0%) Esophagus (8.0%) Head and Neck Kidney Cancer (5.0%) Kidney Disease (5.0%) Larynx Leukemia (3.0%) Liver Cancer (10.0%) Lung (8.0%) Non Hodgkins Lymphoma (8.0%) Pancreas (13.0%) Prostate (24.0%) Stomach (7.0%) Testes |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
"""The ATBC Study, a project between Finland's National Public Health Institute (NPHI) and NCI, was conducted to determine whether daily supplementation with alpha-tocopherol, beta-carotene, or both, would reduce the incidence of lung or other cancers. Male smokers between the ages of 50 and 69 were recruited from southwestern Finland between April 1985 and June 1988. A total of 29,133 men were randomly assigned to one of four intervention groups: 50 mg/day alpha-tocopherol (as dl-alpha-tocopheryl acetate); 20 mg/day beta-carotene; both alpha-tocopherol and beta-carotene; or placebo. They were followed for five to eight years during the trial, until death, or 30 April 1993 when intervention was stopped (median follow-up, 6.1 years). Follow-up for endpoints was continued postintervention. Current research focus areas include metabolomics, biomarkers, prostate and other cancers, genetics, vitamins, and others. Twenty eight years of observational follow-up provides substantial case numbers and study power for the range of hypotheses being tested.""" |