ZIA CP010226-10693 (ZIA) | |||
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Title | Military Cohort Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hoover, Robert | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $171,231 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (100.0%) Contraception and Reproduction Research (50.0%) Diabetes (50.0%) Metastasis (100.0%) |
N/A | ||
Research Type | |||
Resources and Infrastructure Related to Etiology Resources and Infrastructure Related to Detection, Diagnosis, or Prognosis |
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Abstract | |||
"""Our overarching objective is to build a new prospective multi-center adult cohort study set in Tricare with rich exposure information and accurate outcome information that will be used as a Division-wide resource to investigate novel hypotheses about the etiology of cancer by combining questionnaire data, medical records, tumor tissue and serial biospecimens. Given the large-scale nature of the planned cohort study, we propose to conduct a feasibility study at two local military treatment facilities, Walter Reed National Medical Center and Fort Belvoir Community Hospital. The feasibility study will have two parts: 1) we will randomly select and invite by mailed letter a stratified sample of 1,000 eligible beneficiaries aged 35-74 years old without a prior diagnosis of cancer to participate. All participants will complete an on-line consent form which includes consent for access to electronic health records, complete an on-line questionnaire, and provide a blood specimen at either military treatment facility within three months of enrolling in the study. We will evaluate the following outcomes: the % enrollment, % questionnaire completion, % agreement to blood draw, % completion of blood draws, the time between enrollment and blood draw, duration of enrollment in Tricare, % with supplemental civilian insurance, feasibility of linking electronic patient databases to each other and to the questionnaire data, completeness, timeliness, and accuracy of medical record data using standard reports available from the Military Health System Data Repository, and available characteristics of the participants and the non-participants; 2) we will select a stratified random sample of 200 otherwise eligible beneficiaries who have had a cancer diagnosis other than non-melanoma skin cancer within the previous 12 months. We will determine the % of cancers with stored material and the location of that material. No tumor tissue will be collected. """ |