ZIA CP010168 10418 (ZIA) | |||
---|---|---|---|
Title | Mongolia Hormone Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hoover, Robert | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $211,524 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
|||
Abstract | |||
There were striking differences in breast cancer incidence rates between Asian and North American and Western European populations, but within Asia variation was also wide. Incidence in Mongolia was one of the lowest in the world (6.6/100,000) while China, its neighbor to the south, had about three times this rate (18.7/100,000). Furthermore, rates appeared higher in urban than in rural areas. Over the last decade and a half Mongolia has experienced profound economic changes resulting in mass migration from a nomadic or semi-nomadic existence to a more western lifestyle in the capital city of UlaanBaatar. Together with the contrast in exposures between traditional and urban settings, migration presented the opportunity to study women as they acculturated to a more western lifestyle. We proposed collecting maternal and cord blood samples from pregnant Mongolian women and their offspring living in rural and urban areas to describe concentrations of several steroid hormones and growth factors. The purpose of the study was to assess whether the in utero environment differed in women living a traditional lifestyle compared with a more urban lifestyle, and by degree of Western acculturation among those who had recently migrated to the capital. In addition, we planned to study the endocrine profile of pre-menopausal women living in UlaanBaatar by their migration status among mothers of girls participating in a study of milk consumption and hormonal status conducted by our collaborators at Harvard Medical School. Reproductive hormones were measured and are being compared to those in women living in the UK. |