ZIA CP005803 08290 (ZIA) | |||
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Title | VHL | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Caporaso, Neil | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $52,954 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (15.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Chemoprevention (10.0%) Behavioral and Social Science (15.0%) |
Brain (30.0%) Kidney Cancer (40.0%) Kidney Disease (40.0%) |
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Research Type | |||
Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors Interventions to Prevent Cancer: Personal Behaviors (Non-Dietary) that Affect Cancer Risk |
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Abstract | |||
The Von Hippel-Lindau (VHL) Disease Genetic Epidemiology Study is a family-based case-control study of 546 study participants with the goal of examining how the expression of VHL tumors is associated with lifestyle factors (tobacco and alcohol use, physical activity), occupational exposures, reproductive and hormonal factors, medication use, diet, and putative susceptibility genes. This study provides the potential to benefit people with VHL disease (although not necessarily the study subjects themselves) and possibly people with sporadic (non-hereditary) forms of the tumors that occur in VHL disease. Primary comparisons will be between VHL patients with a particular manifestation and VHL patients who are free of that condition. Additional comparisons may be made with unaffected family members who lack a mutation in the VHL gene, as appropriate. |